Description
Potent and selective BRPF bromodomain inhibitor
NI 57 is a potent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively, which exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. NI 57 inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.
| Chemical Name or Material | 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide |
| CAS | 1883548-89-7 |
| Quantity | 50 mg |
| Target | Bromodomain Inhibitors |
| Molecular Formula | C19H17N3O4S |
| Formula Weight | 383.42 |
| Purity | 98% |
