Description
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Specifications
| Antigen | PCDHA1 |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Gene | PCDHA1 |
| Gene Alias | KIAA0345-like 13; PCDHA1; PCDH-ALPHA1; PCDH-alpha-1; protocadherin alpha 1; protocadherin alpha-1; RPF1 |
| Host Species | Rabbit |
| Purification Method | Antigen affinity chromatography |
| Regulatory Status | RUO |
| Gene ID (Entrez) | 116731 |
| Content And Storage | -20°C |
| Form | Liquid |
| Applications | Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot |
| Concentration | 1 mg/mL |
| Formulation | PBS with 50% glycerol and 0.05% ProClin 300 |
| Gene Accession No. | 0 |
| Gene Symbols | PCDHA1 |
| Immunogen | Recombinant protein Protocadherin Alpha 1 |
| Quantity | 200 μL |
| Primary or Secondary | Primary |
| Target Species | Mouse |
| Product Type | Antibody |
| Isotype | IgG |
Safety and Handling
WARNING: Cancer – www.P65Warnings.ca.gov
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