Description
The NFkB transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A cDNA has been isolated that encodes an alternative DNA binding subunit of NFkB. It is synthesized as a protein that is expressed in a variety of cell types and, like p105, undergoes cleavage to generate its NFkB subunit, in this case a protein designated p52 (previously referred to as p49). In contrast to p50 derived from p105, p52 acts in synergy with p65 to stimulate the HIV enhancer in transiently transfected Jurkat cells.
Specifications
| Antigen | NF-kB p100/p52 |
| Classification | Monoclonal |
| Concentration | 1 mg/mL |
| Formulation | PBS with 0.05% sodium azide |
| Gene Accession No. | Q00653, Q9WTK5 |
| Gene Symbols | Nfkb2 |
| Immunogen | Purified recombinant fragment of human NFKB2 (AA: 712-900) expressed in E. Coli. |
| Quantity | 100 μg |
| Primary or Secondary | Primary |
| Target Species | Human, Mouse |
| Form | Liquid |
| Applications | ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot |
| Clone | 5E6A12 |
| Conjugate | Unconjugated |
| Gene | Nfkb2 |
| Gene Alias | CVID10; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; lyt; LYT10; LYT-10; NF kappaB2; NF KB; NF-kappaB2; nfkb p100; NFKB, p52/p100 subunit; NFKB2; NF-kB2; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit 2; nuclear factor Kappa-B, subunit 2; nuclear factor NF-kappa-B p100 subunit; Nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; oncogene Lyt-10; p100; p49; p49/p100; p50B; p52; RGD1307189; transcription factor NFKB2 |
| Host Species | Mouse |
| Purification Method | Protein G |
| Regulatory Status | RUO |
| Gene ID (Entrez) | 18034, 4791 |
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Isotype | IgG1 |
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