Description
Specificity/Activity: Neutralizes pig IFN alpha on A549/MDBK cells in a cytopathic effect inhibition assay. Purity is >95%. Endotoxin level <1 EU/ug. Packaged by and distributed for PBL Assay Science.
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
Specifications
| Antigen | IFN alpha |
| Classification | Monoclonal |
| Concentration | 1.8 mg/mL |
| Formulation | 25mM citrate, 25mM sodium phosphate with 50% glycerol and no preservative; pH 6.5 |
| Gene Accession No. | P49879 |
| Gene Symbols | IFNA1 |
| Immunogen | Porcine Interferon Alpha |
| Quantity | 500 μg |
| Primary or Secondary | Primary |
| Target Species | Pig |
| Product Type | Antibody |
| Isotype | IgG1 |
| Applications | Neutralization |
| Clone | F17 |
| Conjugate | Unconjugated |
| Gene | IFNA1 |
| Gene Alias | alpha-2a interferon; Gm12597; ifa; Ifa1; Ifa2; IFL; IFN; IFN alpha; IFN alpha 1/13; IFN alpha 1b; IFN a; IFN1@; IFNA; IFNA@; IFNA1; IFNA13; Ifna15; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFNA3; IFNA6; Ifnaa; IFNAalphaIFN-alpha-1/13; IFNalpha; IFN-alpha; IFN-alpha 1b; IFN-alpha1; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFN-alpha-6; IFN-alphaA; IFN-alphaD; IFN-gamma; IFNa; INFA2; interferon; interferon alpha; interferon alpha 1; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); interferon alpha protein; interferon alpha-1; Interferon alpha1 (IFNA1); interferon alpha-1 precursor; interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); interferon type A1/A2; interferon type A3; interferon, alpha 1; interferon, alpha 2; interferon-alpha; interferon-alpha 1; interferon-alpha1; interferon-alpha-6; leIF A; LeIF D; MGC138207; MGC138505; MGC138507; MuIFN-alpha-A; novel interferon alpha (Ifna) family member; OTTMUSG00000007655 |
| Host Species | Mouse |
| Purification Method | Protein G |
| Regulatory Status | RUO |
| Gene ID (Entrez) | 397686 |
| Content And Storage | -20°C |
| Form | Liquid |
Cole-Parmer TSI AVM430-A CompuFlow Thermoanemometer, manual datalogging