Description
Description
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq
Sequence: MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDTTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN
Specifications
| Antigen | fibrillarin |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Formulation | PBS with no preservative; pH 7.4 |
| Gene Accession No. | BC019260 |
| Gene Symbols | FBL |
| Immunogen | FBL (AAH19260.1, 1 a.a. ∼ 321 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Quantity | 100 μg |
| Whole Molecule | Yes |
| Gene ID (Entrez) | 2091 |
| Content And Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Isotype | IgG2a κ |
| Applications | ELISA |
| Clone | 3E10 |
| Description | Mouse monoclonal antibody raised against a full length recombinant FBL. |
| Gene | FBL |
| Gene Alias | FIB/FLRN/RNU3IP1 |
| Host Species | Mouse |
| Purification Method | Affinity Purified |
| Regulatory Status | RUO |
| Primary or Secondary | Primary |
| Target Species | Human |
| Product Type | Antibody |
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