Description
Induces severe colitis (inflammatory bowel disease) in laboratory animals
Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to trigger colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. Colitis-grade DSS (MW = 36,000 to 50,000) from MP Bio is one of the most widely used products based on peer reviewed scientific publications.
- Induces severe colitis (inflammatory bowel disease)
- Highest sulfur content – 19%
- Highest chirality – +104° of specific rotation
- Lowest pH – 6.2 at 1% solution
| Color | White |
| Chemical Name or Material | Dextran Sulfate Sodium Salt |
| pH | 5 to 7.11 (1% aqueous solution) |
| Physical Form | Powder |
| CAS | 9011-18-1 |
| Boiling Point | 310°C |
| Melting Point | 92°C |
| Molecular Formula | (C6H7O5)m(C6H7O5)n |
| MDL Number | MFCD00081551 |
| Solubility Information | Soluble in water |
| Quantity | 10 g |
| InChI Key | BLFLLBZGZJTVJG-UHFFFAOYSA-N |
| SMILES | *-OC[C@H]1O[C@H](OC[C@H]2O[C@H](-*)[C@H](O[*])[C@@H](O[*])[C@@H]2O[*])[C@H](O[*])[C@@H](O-*)[C@@H]1O[*] |
| IUPAC Name | Dextran sulfate sodium salt |
| Molecular Weight (g/mol) | 40,000 |
| For Use With (Application) | Used for inducing ulcerative colitis in animals and extensively to study colon cancer developing in relation to colonic inflammation |
| Grade | Colitis Grade |
| Moisture | <10% |
| Packaging | Plastic Container |
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