Description
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: AETFRLQFNN KRRLRRPYYP RKALLCYQLT PQNGSTPTRG YFENKKKCHA EICFI
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Specifications
| Antigen | APOBEC3H |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Gene | APOBEC3H |
| Gene Alias | A3H; APOBEC3H; APOBEC-related protein 10; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; ARP10; ARP-10; DNA dC->dU-editing enzyme APOBEC-3H |
| Host Species | Rabbit |
| Purification Method | Antigen affinity chromatography |
| Regulatory Status | RUO |
| Gene ID (Entrez) | 164668 |
| Content And Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Form | Liquid |
| Applications | Immunocytochemistry |
| Concentration | 0.05 μg/mL |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene Accession No. | Q6NTF7 |
| Gene Symbols | APOBEC3H |
| Immunogen | Recombinant protein corresponding to Human APOBEC3H |
| Quantity | 100 μL |
| Primary or Secondary | Primary |
| Target Species | Human |
| Product Type | Antibody |
| Isotype | IgG |
Safety and Handling
WARNING: Cancer – www.P65Warnings.ca.gov
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