Description
Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Specifications
| Antigen | ACVR1B |
| Classification | Polyclonal |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of ACVR1B. |
| Formulation | In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Gene Accession No. | P36896 |
| Gene Symbols | ACVR1B |
| Immunogen | A synthetic peptide corresponding to amino acids 73-122 of human ACVR1B. |
| Regulatory Status | RUO |
| Gene ID (Entrez) | 91 |
| Target Species | Human, Mouse, Rat |
| Form | Liquid |
| Applications | ELISA, Immunofluorescence, Western Blot |
| Conjugate | Unconjugated |
| Dilution | Western Blot (1:500∼1:1000) Immunofluorescence (1:500∼1:1000) ELISA (1:5000) The optimal working dilution should be determined by the end user. |
| Gene | ACVR1B |
| Gene Alias | ACTRIB/ACVRLK4/ALK4/SKR2 |
| Host Species | Rabbit |
| Quantity | 100 μg |
| Primary or Secondary | Primary |
| Test Specificity | This antibody is specific to ACVR1B. |
| Content And Storage | Store at -20°C.Aliquot to avoid repeated freezing and thawing. |
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